Mechanisms of sex determination and transmission ratio distortion in Aedes aegypti

Title: Mechanisms of sex determination and transmission ratio distortion in Aedes aegypti
Authors: Hoang, K.P.
Teo, T.M.
Ho, T.X.
Le, V.S.
Keywords: Aedes aegypti;Culicinae;Meiotic drive;Sex determination;Spermatogenesis;Transformer-2
Issue Date: 2016
Publisher: BioMed Central Ltd.
Citation: Scopus
Abstract: More effective mosquito control strategies are urgently required due to the increasing prevalence of insecticide resistance. The sterile insect technique (SIT) and the release of insects carrying a dominant lethal allele (RIDL) are two proposed methods for environmentally-friendly, species-targeted population control. These methods may be more suitable for developing countries if producers reduce the cost of rearing insects. The cost of control programs could be reduced by producing all-male mosquito populations to circumvent the isolation of females before release without reducing male mating competitiveness caused by transgenes. Results: An RNAi construct targeting the RNA recognition motif of the Aedes aegypti transformer-2 (tra-2) gene does not trigger female-to-male sex conversion as commonly observed among dipterous insects. Instead, homozygous insects show greater mortality among m-chromosome-bearing sperm and mm zygotes, yielding up to 100 males in the subsequent generations. The performance of transgenic males was not significantly different to wild-type males in narrow-cage competitive mating experiments. Conclusion: Our data provide preliminary evidence that the knockdown of Ae. aegypti tra-2 gene expression causes segregation distortion acting at the level of gametic function, which is reinforced by sex-specific zygotic lethality. This finding could promote the development of new synthetic sex distorter systems for the production of genetic sexing mosquito strains.
Description: Parasites and Vectors Volume 9, Issue 1, 28 January 2016, Article number 1331
URI: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1331-x
http://repository.vnu.edu.vn/handle/VNU_123/33151
ISSN: 17563305
Appears in Collections:Bài báo của ĐHQGHN trong Scopus

Nhận xét

Đăng nhận xét

Bài đăng phổ biến từ blog này

Quản lý nhà nước đối với các cơ sở giáo dục mần non ngoài công lập trên địa bàn Quận Thanh Xuân thành phố Hà Nội = Current state management towards non-public pre-schools in the area of Thanh Xuan district

Title:  Quản lý nhà nước đối với các cơ sở giáo dục mần non ngoài công lập trên địa bàn Quận Thanh Xuân thành phố Hà Nội Other Titles:  Current state management towards non-public pre-schools in the area of Thanh Xuan district Authors:  Ngô, Mỹ Linh Keywords:  Quản lý nhà nước;Giáo dục mầm non Issue Date:  2014 Publisher:  H. : ĐHKHXH&NV Citation:  94 tr. URI:  http://repository.vnu.edu.vn/handle/VNU_123/12336 Appears in Collections: Luận văn - Luận án (LIC)
Đọc thêm

Training and firm performance in economies in transition: a comparison between Vietnam and China

Hình ảnh
This paper provides a comparative analysis on the role of training and its impact on firm performance in some economies in transition in Asia. The starting point is an examination of country contexts and training, and how these have shaped organizational approaches to human resource (HR) training. The paper also reviews the results of recent studies that have investigated the relationship between training and firm performance in Vietnam and China. The review results show that training is positively related to firm performance and reveals some convergence of HR training in both countries. On the basis of this, some caveats on HR training development in the future in these two countries are given. The paper ends with theoretical and practical implications Title:  Training and firm performance in economies in transition: a comparison between Vietnam and China Authors:  Nguyen, Ngoc Thang Quang Truong Buyens, Dirk Keywords:  Economies in transition Firm performance H...
Đọc thêm

Two-point Green functions of free Dirac fermions in single-layer graphene ribbons with zigzag and armchair edges

Green function technique is a very efficient theoretical tool for the study of dynamical quantum processes in many-body systems. For the study of dynamical quantum processes in graphene ribbons it is necessary to know two-point Green functions of free Dirac fermions in these materials. The purpose of present work is to establish explicit expressions of two-point Green functions of free Dirac fermions in single-layer graphene ribbons with zigzag and armchair edges. By exactly solving the system of Dirac equations with appropriate boundary conditions on the edges of graphene ribbons we derive formulae determining wave functions of free Dirac fermions in above-mentioned materials. Then the quantum fields of free Dirac fermions are introduced, and explicit expressions of two-point Green functions of free Dirac fermions in single-layer graphene ribbons with zigzag and armchair edges are established. Title:  Two-point Green functions of free Dirac fermions in single-layer...
Đọc thêm