Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharideinduced acute liver injury in mice

To investigated the protective potential of ethanol extracts of Scutellaria baicalensis (S. baicalensis) against lipopolysaccharide (LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS (5 mg/kg of body weight, intraperitoneal injection). Both protein and mRNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. Cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-kB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS significantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver mice. Conclusions: Our study showed that S. baicalensis is potentially protective against LPSinduced liver injury in mice.

Title: 

Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharideinduced acute liver injury in mice
Authors: Nguyen, Thanh Hai
Pham, Thi Minh Hue
Le, Tuan Anh
Vu, Duc Loi
Duong, Thi Ly Huong
Nguyen, Huu Tung
Dang, Kim Thu
Bui, Thanh Tung
Keywords: alcohol
antiinflammatory activity
Scutellaria baicalensis
Lipopolysaccharide
Liver injury
Nuclear factor-κB
Issue Date: 2015
Publisher: Hainan Medical University
Citation: Scopus
Abstract: Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis (S. baicalensis) against lipopolysaccharide (LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS (5 mg/kg of body weight, intraperitoneal injection). Both protein and mRNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. Cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-kB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS significantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver mice. Conclusions: Our study showed that S. baicalensis is potentially protective against LPSinduced liver injury in mice.
Description: Asian Pacific Journal of Tropical Biomedicine, Volume 5, Issue 9, April 20, 2015, Pages 761-767
URI: http://www.sciencedirect.com/science/article/pii/S2221169115001410
http://repository.vnu.edu.vn/handle/VNU_123/32406
ISSN: 22211691
Appears in Collections:Bài báo của ĐHQGHN trong Scopus

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